POS0764 CLINICAL AND LABORATORY FINDINGS IN PRIMARY SJOGREN’S SYNDROME PATIENTS WITHOUT SUBJECTIVE SICCA SYMPTOMS

Background Sjogren’s syndrome (SS) is a systemic autoimmune rheumatic disease characterized by symptoms of dryness. In fact, subjective manifestations dry eyes or mouth are part the inclusion criteria 2016 ACR-EULAR Classification Criteria for primary SS (pSS). However, some patients with diagnosis may present without dryness, meeting based on EULAR activity index (ESSDAI) questionnaire (1). Studies non-dryness missing. Objectives To describe clinical phenotype pSS who lack dryness symptoms. Methods From 1738 consecutive fulfill and were followed up in 4 centers from Greece Italy (Universities Athens, Pisa, Harokopio Ioannina) (PAHI group), those sicca identified (non-Dryness Group) Cumulative, clinical, laboratory, immunologic histologic data collected compared age, gender duration-matched both oral eye 1:2 ratio (Dryness (Table 1). Statistical analysis categorical was performed Fisher exact test χ2 square accordingly numerical Mann-Whitney t test. Table 1. Comparison laboratory features (Non-dryness Clinical Laboratory Non-Dryness Group, %, n=38 Dryness n=76 p-value ANA positivity % 100 95.9 0.55 RF 58.3 64.3 0.7 Anti-Ro 90.8 0.09 Anti-La 54.1 50.7 0.89 Salivary gland biopsy 93.9 89.8 0.71 Focus score 2.12 2.19 0.97 Ocular tests 55.6 <0.001 enlargement 26.3 30.3 0.83 Arthralgias 52.6 56.6 0.84 Arthritis 25.7 17.6 0.48 Raynaud’s phenomenon 23.7 27.6 0.82 Palpable purpura 7.9 18.4 0.17 Lymphadenopathy 22.6 20.3 0.99 Leukopenia 20.7 26.1 0.76 Lymphopenia 0 17.3 0.049 Neutropenia 20.8 5.8 0.1 Thrombocytopenia 13.8 3.1 0.07 Low C4 23.3 0.65 Cryoglobulinemia 10.5 3.9 0.3 Lymphoma 10.8 6.7 0.47 Results Thirty-eight found (2.19%). The most common presenting manifestation arthralgias (47.4%), parotid (23.6%), (10.5%), generalized lymphadenopathy fatigue palpable (5.3%) pulmonary symptomatology cough exertional dyspnea (5.3%). Despite ocular group had positive but statistically lower to (55.6% vs 93.9%, p<0.001), displayed lymphopenia less frequently (0 17.3%, p=0.049). No statistical differences terms salivary (SGE), focus (FS), cryoglobulinemia autoantibody profile between 2 groups. Conclusion similar underlying immunopathologic processes as typical patients. References [1]Shiboski CH, Shiboski SC, Seror R, Criswell LA, Labetoulle M, Lietman TM, et al. American College Rheumatology/European League Against Rheumatism Primary Syndrome: A Consensus Data-Driven Methodology Involving Three International Patient Cohorts. Rheumatol. 2017;69(1):35-45. Disclosure Interests None declared